In a recent study, Lily Li-Wen Wang et al. found that macrophage-adhering GLAMs can be used to identify the presence of mild traumatic brain injuries (mTBIs) that do not show up on standard MRI brain scans.

Results from a recent study published in the Clinical Journal of Sports Medicine indicated that youth with exercise-induced vision dysfunction following sport-related concussion were at “a 3-folder greater risk” of developing persistent post-concussive symptoms (PPCS) compared to those without exercise-induced vision dysfunction.

A study published in the Journal of Neuroinflammation found that athletes with PPCS due to sports-related concussions (SRC) have elevated levels of inflammation in the brain. Of 27 cerebrospinal fluid (CSF) biomarkers of inflammation tested for, eight were significantly higher in athletes with PPCS compared to healthy controls.

Increase in delta brain waves may indicate the presence of a concussion and that measuring delta waves may be a potential diagnostic tool.

"Adults over the age of 75 have had the highest incidence of traumatic brain injuries" and better diagnostic tools are needed. BrainBox has received a grant to create a clinical solution that accurately captures the diagnosis and prognosis of mTBI in elderly patients.

A study by Dr. Lyndsey M. Ferris et al., published in the American Journal of Sports Medicine, analyzed the utility of baseline evaluations for identifying acute concussions in college athletes. The researchers found that using baseline evaluations does not significantly improve diagnostic accuracy.

A study by Ghazala T. Saleem et al. examined the efficacy of the Physical and Neurological Examination of Subtle Signs (PANESS) to identify subtle postural control deficits after concussion. They found that the thirty-second single-leg stance identified impaired postural control in children after concussion.

A study by Dr. Michael Robinson et al., published in American Journal of Physical Medicine & Rehabilitation, used a decision tree to identify patients at higher risk of developing prolonged concussion symptoms. The researchers found that feelings of fogginess and sadness at initial assessment were predictive of prolonged symptoms “lasting 28 days or more postconcussion.”

A study by Cassandra C. Daisy et al. published in Neurology discovered a new pair of proteins in urine that, along with a single-task gait evaluation, can be used to distinguish concussed athletes from healthy controls with 83.5% accuracy.

The top-flight of English football, the Premier League (PL), announced plans to administer saliva tests that could potentially diagnose concussions sustained during games or training sessions. The trial, an academic study funded by the Premier League and intended to validate salivary biomarkers as a diagnostic tool, may start sometime this season (which ends in May 2022).