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Psychiatric symptoms caused by multiple concussions may be due to the kynurenine pathway and structural changes in the brain in collegiate-aged athletes
A study investigated the link between concussion history, changes in limbic brain structure (the emotional processing system), and psychiatric symptoms, focusing on the kynurenine pathway (KP) as a potential mechanism. The KP is a metabolic pathway connected to inflammation, the immune system, and neurological conditions.
Blood biomarkers detect reduced brain structure volume associated with repetitive head impacts in professional boxers and MMA fighters
A study in Neurology Advisor found that for active and retired professional fighters exposed to repetitive head impacts, blood plasma measurements of the biomarkers GFAP and NfL “may help identify those who are at risk for progressive regional brain atrophy and cognitive decline.”
Study Highlights the Importance of Delaying Return to Activities in Symptomatic Concussion Patients
A paper published in the Journal of Neurotrauma found that children with persistent symptoms had imaging “evidence of ongoing microstructural reorganization or neuroinflammation,” highlighting the importance of delaying a child’s return to play following a concussion if symptoms are persisting.
Neuroinflammation found in athletes with persistent post-concussive symptoms (PPCS)
A study published in the Journal of Neuroinflammation found that athletes with PPCS due to sports-related concussions (SRC) have elevated levels of inflammation in the brain. Of 27 cerebrospinal fluid (CSF) biomarkers of inflammation tested for, eight were significantly higher in athletes with PPCS compared to healthy controls.